Mus musculus
Melatonin receptor KO mouse
C3H MT1−/− knock-out mice homozygous for the rd1 mutation, generously donated by Drs. Reppert and Weaver (University of Massachusetts Medical School), were back-crossed with C3H/f+/+ mice in which the rd1 mutation has been removed to produce C3H/f+/+MT1−/−.
Resource Description
resource_description
Melatonin receptor knockout mouse
Additional Name
eagle-i_synonym
Related Publication or Documentation
has documentation
has_documentation
Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.
Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.
Genetic Alteration(s)
has sequence alteration
has_sequence_alteration
Melatonin receptor knockout
C3H
Parental Strain Name
has parental strain name
has_parental_strain_name
Phenotype Findings
Phenotype
has_phenotype_annotation
25-30% ganglion cells die out by 18months of age
phenotypic annotation
25-30% ganglion cells die out by 18months of age
information content entity
information content entity
conclusion textual entity
conclusion textual entity
continuant
entity
generically dependent continuant
Location
located_in
Gianluca Tosini Laboratory
located in
2011-05-20T14:39:20.816-05:00
nvasilevsky
2011-05-20T15:22:04.886-05:00
workflow state
Published
nvasilevsky
Organism or Virus
organism
organism
Mus <mouse, genus>
Mammalia
Rodentia
Organism
non viral organism
Chordata
Vertebrata <Metazoa>
Glires
material_entity
independent_continuant
continuant
entity