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Xuebiao Yao, Ph.D.

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    Our primary research goal is to study the role of cytochrome P450 (CYP) metabolites in the regulation of vascular and renal function. Obesity and type 2 diabetes not only cause metabolic abnormalities but also markedly affect vascular function, in particular endothelium-dependent agonist-induced vasorelaxation. Prostacyclin, nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) are the main contributors to the endothelium-dependent vasodilation. Arachidonic acid CYP epoxygenase metabolites, epoxyeicosatrienoic acids (EETs), are potent vasodilators and they are EDHFs in the renal and mesenteric microcirculations. We have recently demonstrated that obesity and type 2 diabetes are associated with a decrease in CYP enzymes in the renal and mesenteric arteries. We are currently examining the regulatory mechanism and functional consequence of CYP metabolites in the development and progression of vascular and renal dysfunction in obesity and diabetes. Aging is another important cardiovascular risk factor. Both morbidity and mortality are dramatically increased when aging process is associated with hypertension and obesity, a frequent pathology in the elderly population. Vascular aging is also mainly characterized by an impaired endothelium-dependent relaxation. A recent study has suggested that not only a defect in the NO pathway, but also a loss of EDHF-mediated responses may be responsible for impaired vasodilation in the aging kidney. We are also interested in studying the specific contribution of CYP metabolites to the regulation of endothelial function in aged kidneys.
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    wroth (William Roth)
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    sgarneradm (Solomon Garner)
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