This is a summary list of all laboratories at Morehouse School of Medicine . The list includes links to more detailed information, which may also be found using the eagle-i search app.
Nearly all biological functions, in nearly all organisms, are organized in the time domain. The daily appearance and disappearance of environmental light during evolution provided a framework within which animals could consolidate their activity and rest periods. The timing of behavior and other physiological activity is internalized, and is under the control of internal biological clocks called circadian oscillators.
In my lab, using mouse models, we strive to understand how these rhythms are controlled by the master oscillator in the brain, called the SCN. We also try to understand the consequences of disrupting the normal temporal harmony in the organism. For example, shift work is common in our society, and carries with it numerous health consequences such as increased rates of cancer. Our animal models simulate such lifestyles, and our studies are designed to determine exactly what is causing disease in these environments, and how this can be prevented.
Research in Dr Tosini’s laboratory focuses on the roles that melatonin and the circadian clock play in the regulation of retinal physiology and pathophysiology. We have a series of Transgenic mice in which the melatonin receptors have been removed (melatonin receptors KO).
Dr. Hibbert’s primary research focus is nutritional implications of altered metabolism in sickle cell disease (SCD). Dr. Hibbert’s research projects include: protein, energy and hemoglobin metabolism in stable SCD patients; relationship of metabolic alterations, nutritional status and immune response in SCD; potential health benefits of nutritional supplements in SCD patients and transgenic mouse model; genetic modifiers of SCD severity focusing on pathways for energy and protein metabolism and proinflammatory factors, using stored human plasma and DNA; temporal changes of proinflammatory markers in tissues and effect of L-arginine supplement using the SCD transgenic mouse. Dr. Hibbert collaborates with Dr. Stiles, Dr. Gee and Dr. Newman at MSM and with colleagues at Emory University and Medical College of Georgia.
Being overweight or obese increases the risk of the development of many diseases such as diabetes and cardiovascular diseases. It is known that the proliferation, differentiation and apoptosis of preadipocytes are all related to the hyperplasia of adipose tissue. Mitochodrial biogenesis has been reported to accompany with brown and white adipose cell differentiation. Prohibitins are highly conserved proteins mostly locating in mitochondria and play important roles in the proliferation, differentiation and apoptosis in a lot of different types of cells. One of the interests in Dr. Liu's laboratory is focused on the role of prohibitins during adipogenesis.
The emerging field of regenerative medicine will require a reliable and accessible source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose-derived stem cells have demonstrated very similar phenotypic and functional characteristics to that of bone marrow-derived mesenchymal stem cells with the ability to differentiate along multiple lineage pathways besides adipocyte. Another interest in Dong Liu's laboratory is to define the role of prohibitins in regenerative capacity of adult stem cells by testing the effect of prohibitins on adipose-derived stem cells differentiation into cardiomyocytes, endothelial cells and smooth muscle cells.
Found 6 laboratories .