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Melatonin receptor KO mouse

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    C3H MT1−/− knock-out mice homozygous for the rd1 mutation, generously donated by Drs. Reppert and Weaver (University of Massachusetts Medical School), were back-crossed with C3H/f+/+ mice in which the rd1 mutation has been removed to produce C3H/f+/+MT1−/−.
  2. Additional Name
    Melatonin receptor knockout mouse
  3. Related Publication or Documentation
    Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.
  4. Related Publication or Documentation
    Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.
  5. Parental Strain Name
  6. Genetic Alteration(s)
    Melatonin receptor knockout
  7. Phenotype Findings
    25-30% ganglion cells die out by 18months of age
  8. Location
    Gianluca Tosini Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016