Melatonin receptor KO mouse

eagle-i ID

Resource Type

Properties

1. Resource Description

   C3H MT1−/− knock-out mice homozygous for the rd1 mutation, generously donated by Drs. Reppert and Weaver (University of Massachusetts Medical School), were back-crossed with C3H/f+/+ mice in which the rd1 mutation has been removed to produce C3H/f+/+MT1−/−.

2. Additional Name

   Melatonin receptor knockout mouse

3. Related Publication or Documentation

   Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.

4. Related Publication or Documentation

   Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.

5. Parental Strain Name

   C3H

6. Genetic Alteration(s)

   Melatonin receptor knockout

7. Phenotype Findings

   25-30% ganglion cells die out by 18months of age

8. Location

   Gianluca Tosini Laboratory